TimingSaccharomyces boulardii

Anytime, stay consistent

When to take Saccharomyces boulardii

Anytime; safe alongside antibiotics

Saccharomyces boulardii is a probiotic yeast, so antibiotics don't kill it. It's well studied for antibiotic-related and travellers' diarrhoea.

Updated 2026-10-25

Best time in your day

Any time of day: pick a time that suits you and keep it the same every day.

When
Anytime; fine alongside antibiotics
Food
With or without food
Typical dose
250–500 mg (5–10 billion CFU) once or twice daily

How to take it

  1. 1Start on the first day of antibiotics
  2. 2Continue a week after finishing
  3. 3Take it before travel
  4. 4Use for 2–4 weeks

Watch out

Avoid it if you're immunocompromised or have a central line, because of a rare risk of bloodstream infection.

Keep apart from

  • Antifungal medicine

Common questions

Can I take it with antibiotics?

Yes, it's a yeast so antibiotics don't harm it.

Is it the same as baker's yeast?

It's a related strain, but not the same.

Does it help IBS?

Some studies suggest benefit.

Explore further

Commonly used for

Sources

  1. NIH Office of Dietary Supplements: Probiotics fact sheet for health professionals

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For general education only, not medical advice. Talk to a qualified doctor before starting or changing supplements, especially if you are pregnant, nursing or on medication.